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Article
Peer Reviewed

[ 11 C]Ascorbic and [ 11 C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography

Carroll, VN;
Truillet, C;
Shen, B;
Flavell, RR;
Shao, X;
Evans, MJ;
VanBrocklin, HF;
Scott, PJH;
Chin, FT;
Wilson, DM

UC San Francisco Previously Published Works (2016)

Here we report the radiosynthesis of an endogenous redox pair, [(11)C]ascorbic acid ([(11)C]VitC) and [(11)C]dehydroascorbic acid ([(11)C]DHA), the reduced and oxidized forms of vitamin C, and their application to ROS sensing. These results provide the basis for in vivo detection of ROS using positron emission tomography (PET).

Cover page: [ 11 C]Ascorbic and [ 11 C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography