- Liu, Jamin;
- Laurie, Matthew T;
- Rubio, Luis;
- Vazquez, Sara E;
- Sunshine, Sara;
- Mitchell, Anthea M;
- Hapte-Selassie, Matthias;
- Mann, Sabrina A;
- Pilarowski, Genay;
- Black, Douglas;
- Marquez, Carina;
- Rojas, Susana;
- Lionakis, Michail S;
- Petersen, Maya;
- Whitman, Jeffrey D;
- Jain, Vivek;
- Anderson, Mark;
- Havlir, Diane;
- DeRisi, Joseph
While SARS-CoV-2 vaccines prevent severe disease effectively, postvaccination "breakthrough" COVID-19 infections and transmission among vaccinated individuals remain ongoing concerns. We present an in-depth characterization of transmission and immunity among vaccinated individuals in a household, revealing complex dynamics and unappreciated comorbidities, including autoimmunity to type 1 interferon in the presumptive index case.