The mechanical behavior of ultra-fine-grained (UFG) INCONEL 625 superalloy prepared via cryomilling and spark plasma sintering (SPS) was studied. The work-hardening response of the ultra-fine-grained (600 to 700 nm) INCONEL 625 was compared to that of the material with a 1-μm grain size and the results showed normal work hardening for the latter material but not for the former. Moreover, the results suggest that a combination of high strength and good ductility can be simultaneously obtained in the UFG INCONEL 625 alloy.