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Scholarly Works (1 results)

Article
Peer Reviewed

Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423

McCormick, Frank;
Kashiyama, T;
Oda, K;
Ikeda, Y;
Shiose, Y;
Hirota, Y;
Inaba, K;
Makii, C;
Kurikawa, R;
Miyasaka, A;
Koso, T

UC San Francisco Previously Published Works (2014)

DS-7423, a novel, small-molecule dual inhibitor of phosphatidylinositol-3- kinase (PI3K) and mammalian target of rapamycin (mTOR), is currently in phase I clinical trials for solid tumors. Although DS-7423 potently inhibits PI3Kα (IC50 = 15.6 nM) and mTOR