Skip to main content
Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423
Published Web Location
http://europepmc.org/articles/PMC3913610?pdf=renderNo data is associated with this publication.
Abstract
DS-7423, a novel, small-molecule dual inhibitor of phosphatidylinositol-3- kinase (PI3K) and mammalian target of rapamycin (mTOR), is currently in phase I clinical trials for solid tumors. Although DS-7423 potently inhibits PI3Kα (IC50 = 15.6 nM) and mTOR
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.