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Scholarly Works (2 results)

Article
Peer Reviewed

Large-Scale Determination of Sequence, Structure, and Function Relationships in Cytosolic Glutathione Transferases across the Biosphere

Babbitt, Patricia;
Mashiyama, ST;
Malabanan, MM;
Akiva, E;
Bhosle, R;
Branch, MC;
Hillerich, B;
Jagessar, K;
Kim, J;
Patskovsky, Y;
Seidel, RD

UC San Francisco Previously Published Works (2014)

The cytosolic glutathione transferase (cytGST) superfamily comprises more than 13,000 nonredundant sequences found throughout the biosphere. Their key roles in metabolism and defense against oxidative damage have led to thousands of studies over several de

Article
Peer Reviewed

Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function

Jacobson, Matthew;
Babbitt, Patricia;
Kim, J;
Xiao, H;
Bonanno, JB;
Kalyanaraman, C;
Brown, S;
Tang, X;
Al-Obaidi, NF;
Patskovsky, Y;
Babbitt, PC;
Jacobson, MP

UC San Francisco Previously Published Works (2013)

The identification of novel metabolites and the characterization of their biological functions are major challenges in biology. X-ray crystallography can reveal unanticipated ligands that persist through purification and crystallization. These adventitious