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Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function

  • Author(s): Jacobson, Matthew;
  • Babbitt, Patricia;
  • Kim, J;
  • Xiao, H;
  • Bonanno, JB;
  • Kalyanaraman, C;
  • Brown, S;
  • Tang, X;
  • Al-Obaidi, NF;
  • Patskovsky, Y;
  • Babbitt, PC;
  • Jacobson, MP
  • et al.

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The identification of novel metabolites and the characterization of their biological functions are major challenges in biology. X-ray crystallography can reveal unanticipated ligands that persist through purification and crystallization. These adventitious

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