- Klein, Ophir;
- Ho, Sunita;
- Biehs, B;
- Hu, JKH;
- Strauli, NB;
- Sangiorgi, E;
- Jung, H;
- Heber, RP;
- Goodwin, AF;
- Dasen, JS;
- Capecchi, MR
The polycomb group gene Bmi1 is required for maintenance of adult stem cells in many organs. Inactivation of Bmi1 leads to impaired stem cell self-renewal due to deregulated gene expression. One critical target of BMI1 is Ink4a/Arf, which encodes the cell-
