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Article
Peer Reviewed

Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial.

Oldenburg, Catherine E;
Hinterwirth, Armin;
Sié, Ali;
Coulibaly, Boubacar;
Ouermi, Lucienne;
Dah, Clarisse;
Tapsoba, Charlemagne;
Cummings, Susie L;
Zhong, Lina;
Chen, Cindi;
Sarkar, Samarpita;
Bärnighausen, Till;
Lietman, Thomas M;
Keenan, Jeremy D;
Doan, Thuy

UC San Francisco Previously Published Works (2020)

We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics.

Cover page: Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial.