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Article
Peer Reviewed

Common and Divergent Features of Galactose-1-phosphate and Fructose-1-phosphate Toxicity in Yeast

Gibney, Patrick A;
Schieler, Ariel;
Chen, Jonathan C;
Bacha-Hummel, Jessie M;
Botstein, Maxim;
Volpe, Matthew;
Silverman, Sanford J;
Xu, Yifan;
Bennett, Bryson D;
Rabinowitz, Joshua D;
Botstein, David
Editor(s): Drubin, David G

UC Berkeley Previously Published Works (2018)

Metabolic dysregulation leading to sugar-phosphate accumulation is toxic in organisms ranging from bacteria to humans. By comparing two models of sugar-phosphate toxicity in Saccharomyces cerevisiae, we demonstrate that toxicity occurs, at least in part, through multiple, isomer-specific mechanisms, rather than a single general mechanism.

Cover page: Common and Divergent Features of Galactose-1-phosphate and Fructose-1-phosphate Toxicity in Yeast