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Common and Divergent Features of Galactose-1-phosphate and Fructose-1-phosphate Toxicity in Yeast

et al.

Published Web Location

https://doi.org/10.1091/mbc.e17-11-0666
Creative Commons 'BY-NC-SA' version 4.0 license
Abstract

Metabolic dysregulation leading to sugar-phosphate accumulation is toxic in organisms ranging from bacteria to humans. By comparing two models of sugar-phosphate toxicity in Saccharomyces cerevisiae, we demonstrate that toxicity occurs, at least in part, through multiple, isomer-specific mechanisms, rather than a single general mechanism.

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