- Korenchan, DE;
- Flavell, RR;
- Baligand, C;
- Sriram, R;
- Neumann, K;
- Sukumar, S;
- VanBrocklin, H;
- Vigneron, DB;
- Wilson, DM;
- Kurhanewicz, J
A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C pH imaging in a phantom and in vivo in a murine model of prostate cancer.