The cross-disciplinary field of resilience engineering has been at the forefront of designing robust, flexible processes to embed this construct into daily practice in a variety of environments. This co-presented session will explore the role of the information, evidence, and knowledge (EIK) necessary to support organizational resilience and to design preemptive responses to expected types of failure and generate learning. Organizations must be able to incorporate the three elements (EIK) as different components of a fully informed organization. By recognizing the skills needed to optimize the use of EIK and strategize programs and initiatives to support a culture that values EIK use as a core element in the quest for organizational resilience, organizations can bolster their reliability. The speakers will discuss how EIK can help their teams respond to and recover from unanticipated events, to quickly bounce back to normal operations, and to design systems to learn from and prevent similar surprises in the future. This session will focus on topics relevant to academic health care, patient safety and engineering.