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Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells

et al.

Published Web Location

https://doi.org/10.1038/nn.4297
Abstract

The authors reveal that PTB and its homolog nPTB mediate two sequential RNA regulatory loops required for converting human adult fibroblasts to functional neurons, and likely required for neurogenesis in vivo. The first loop, PTB–miR-124–REST, controls initial neuronal conversion and the second, nPTB–miR-9–BRN2, is responsible for neuronal maturation.

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