The solvation properties of nitric oxide
- Author(s): Abraham, Michael H;
- Gola, Joelle M. R;
- Cometto-Muniz, J. Enrique;
- Cain, William S
- et al.
Published Web Locationhttps://doi.org/10.1039/b004419i
Literature values for the partition of nitric oxide between the gas phase and water and between the gas phase and organic solvents have been combined to yield water-solvent partition coefficients. Analysis of the gas-solvent and water-solvent partition coefficients using the solvation equations of Abraham shows that nitric oxide has no hydrogen bond acidity at all, and is only a very weak hydrogen bond base. The various solvation descriptors of Abraham for nitric oxide can be obtained, and are shown to be similar to other inorganic gases; the descriptors can be used to predict a large number of physicochemical properties of nitric oxide. The calculated lipophilicity of nitric oxide, as a water-octanol partition coefficient, is very small at 0.58 (logPoct), about the same as argon or nitrogen.