Does Naloxone Reinstate Secondary Hyperalgesia in Humans after Resolution of a Burn Injury? A Placebo-Controlled, Double-Blind, Randomized, Cross-Over Study
- Author(s): Rowbotham, Michael
- Pereira, MP
- Werner, MU
- Ringsted, TK
- Rowbotham, MC
- Taylor, BK
- Dahl, JB
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3669421?pdf=render
Introduction:Development of secondary hyperalgesia following a cutaneous injury is a centrally mediated, robust phenomenon. The pathophysiological role of endogenous opioid signalling to the development of hyperalgesia is unclear. Recent animal studies, ca
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