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Open Access Publications from the University of California

Lifetime exposure to estrogen and progressive supranuclear palsy: Environmental and Genetic PSP study.

  • Author(s): Park, Hee Kyung
  • Ilango, Sindana
  • Charriez, Christina M
  • Checkoway, Harvey
  • Riley, David
  • Standaert, David G
  • Bordelon, Yvette
  • Shprecher, David R
  • Reich, Stephen G
  • Hall, Deborah
  • Kluger, Benzi
  • Marras, Connie
  • Jankovic, Joseph
  • Dubinsky, Richard
  • Litvan, Irene
  • ENGENE-PSP Study
  • et al.

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BACKGROUND:Studies suggesting a protective effect of estrogen in neurodegenerative diseases prompted us to investigate this relationship in progressive supranuclear palsy (PSP). METHODS:This case-control study evaluated the self-reported reproductive characteristics and estrogen of 150 women with PSP and 150 age-matched female controls who participated in the Environmental Genetic-PSP study. Conditional logistic regression models were generated to examine associations of PSP with estrogen. RESULTS:There was no association between years of estrogen exposure duration and PSP. There was a suggestion of an inverse association between composite estrogen score and PSP that did not reach statistical significance (P = .06). Any exposure to estrogen replacement therapy halved the risk of PSP (odds ratio = 0.52; 95% confidence interval = 0.30-0.92; P = .03). Among PSP cases, earlier age at menarche was associated with better performance on Hoehn and Yahr stage (β = -0.60; SE = 0.26; P = .02) and Unified Parkinson's Disease Rating Scale II score (β = -5.19; SE = 2.48; P = .04) at clinical examination. CONCLUSIONS:This case-control study suggests a protective role of lifetime estrogen exposure in PSP. Future studies will be needed to confirm this association. © 2018 International Parkinson and Movement Disorder Society.

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