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Germline Chd8 haploinsufficiency alters brain development in mouse
- Gompers, Andrea L;
- Su-Feher, Linda;
- Ellegood, Jacob;
- Copping, Nycole A;
- Riyadh, M Asrafuzzaman;
- Stradleigh, Tyler W;
- Pride, Michael C;
- Schaffler, Melanie D;
- Wade, A Ayanna;
- Catta-Preta, Rinaldo;
- Zdilar, Iva;
- Louis, Shreya;
- Kaushik, Gaurav;
- Mannion, Brandon J;
- Plajzer-Frick, Ingrid;
- Afzal, Veena;
- Visel, Axel;
- Pennacchio, Len A;
- Dickel, Diane E;
- Lerch, Jason P;
- Crawley, Jacqueline N;
- Zarbalis, Konstantinos S;
- Silverman, Jill L;
- Nord, Alex S
Published Web Location
https://doi.org/10.1038/nn.4592Abstract
Strong genetic evidence points to a significant role for heterozygous mutations to general chromatin remodeling factors, such as CHD8, in autism. Gompers et al. combine genomic, neuroanatomical and behavioral approaches to present an initial integrative picture of transcriptional mechanisms and widespread impacts of Chd8 haploinsufficiency across brain development in mice.
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