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Structural insights into RNA processing by the human RISC-loading complex
- Wang, Hong-Wei;
- Noland, Cameron;
- Siridechadilok, Bunpote;
- Taylor, David W;
- Ma, Enbo;
- Felderer, Karin;
- Doudna, Jennifer A;
- Nogales, Eva
Published Web Location
https://doi.org/10.1038/nsmb.1673Abstract
Despite the importance of small RNA–mediated silencing, no structural information exists for complexes of known function. Using single-particle EM, the structure of the minimal functional unit for RNAi in humans (AGO2, Dicer and TRBP) is now presented.
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