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A PRC1–RNF2 knockout punch for cancer
Published Web Location
https://doi.org/10.1038/s43018-021-00270-0Abstract
Shedding light on epigenetic mechanisms controlling anti-tumor immune responses, a new study shows that the tumor-intrinsic ring finger protein 2 (RNF2), the catalytic subunit of Polycomb repressor complex 1 (PRC1), acts as a negative regulator of a collaborative NK and CD4+ T cell anti-tumor immune response against breast cancer.
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