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Nanomicelle formulation modifies the pharmacokinetic profiles and cardiac toxicity of daunorubicin.

  • Author(s): Zhang, Hongyong;
  • Li, Yuanpei;
  • Lin, Tzu-Yin;
  • Xiao, Kai;
  • Haddad, Ashraf S;
  • Henderson, Paul T;
  • Jonas, Brian A;
  • Chen, Mingyi;
  • Xiao, Wenwu;
  • Liu, Ruiwu;
  • Lam, Kit S;
  • Pan, Chong-xian
  • et al.

Published Web Location

https://doi.org/10.2217/nnm.14.44Creative Commons 'BY-NC-ND' version 4.0 license
Abstract

Background

Treatment with daunorubicin (DNR) in acute myeloid leukemia is moderately effective and associated with significant side effects, including cardiac toxicity. We recently developed a nanomicellar formulation of DNR that specifically targets acute myeloid leukemia stem cells.

Materials & methods

Pharmacokinetics analysis of free DNR, DNR in nanomicellar formulations was performed in Balb/c mice and Sprague-Dawley rats. Histochemical staining, caspase 3/7, troponin and creatine kinase MB isoenzyme were used to assess toxicity.

Results

Compared with free DNR, the nanomicellar formulations of DNR had less cardiotoxicity as evidenced by milder histopathological changes, lower caspase 3/7 activity in heart tissue (p = 0.002), lower plasma creatine kinase MB isoenzyme (p = 0.002) and troponin concentrations (p = 0.001) postinjection. The area under curve concentration of DNR in micelles increased by 31.9-fold in mice (p < 0.0001) and 22.0-fold higher in rats (p < 0.001).

Conclusion

Leukemia stem cell-targeting micelles dramatically change the pharmacokinetics and reduce the cardiac toxicity of DNR, which may enable improved DNR-based treatment of acute myeloid leukemia.

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