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14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′–rich switch regions for class switch recombination

et al.

Published Web Location

https://doi.org/10.1038/nsmb.1884
Creative Commons 'BY' version 4.0 license
Abstract

AID is a DNA cytidine deaminase with a central role in the generation of antibody diversity. AID initiates class switch recombination by modifying DNA within the switch (S) regions in the IgH locus. Now AID is shown to be targeted to the S regions by interaction with adaptor proteins 14-3-3, which in turn bind directly to the DNA motif 5'AGCT.

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