Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men
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Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men

  • Author(s): Barnett, Christine M.
  • Nielson, Carrie M.
  • Shannon, Jackie
  • Chan, June M.
  • Shikany, James M.
  • Bauer, Douglas C.
  • Hoffman, Andrew R.
  • Barrett-Connor, Elizabeth
  • Orwoll, Eric
  • Beer, Tomasz M.
  • et al.
Abstract

Multiple studies have shown clear evidence of vitamin D’s anti-tumor effects on prostate cancer cells in laboratory experiments, but the evidence has not been consistent in humans. We sought to examine the association between vitamin D and prostate cancer risk in a cohort of older men. We conducted a prospective case-cohort study nested within the multicenter Osteoporotic Fractures in Men (MrOS) study. Baseline serum 25-OH vitamin D was measured in a randomly selected sub-cohort of 1,433 men ≥65 years old without a history of prostate cancer and from all participants with an incident diagnosis of prostate cancer (n = 297). Cox proportional hazards models were used to evaluate the associations between quartiles of total 25-OH vitamin D and incident prostate cancer, as well as Gleason score. In comparison with the lowest quartile of 25-OH vitamin D, the hazard ratio for the highest quartile of 25-OH vitamin D was 1.22 (CI 0.50–1.72, p = 0.25), no trend across quartiles (p = 0.94) or association with Gleason score was observed. Adjustment for covariates did not alter the results. In this prospective cohort of older men, we found no association between serum 25-OH vitamin D levels and subsequent risk of prostate cancer.

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