UCSF

Limited information exists on the effects of self-reported exercise on subjective and objective measures of chemotherapy-induced peripheral neuropathy (CIPN). In this study, we evaluated for differences in demographic and clinical characteristics, as well as subjective and objective measures of CIPN and balance among 290 cancer survivors with CIPN who were classified into one of three exercise (Ex) groups (i.e., NoEx, LessEx, RecEX) based on the recommended level of >150 minutes per week. Survivors completed self-report questionnaires and underwent a sensory examination and balance testing. Compared to RecEx group (34.8%), survivors in the NoEx group (20.7%) had less education, were less likely to be married/partnered, had a lower household income, a higher level of comorbidity, and a poorer functional status. No differences were found among the three exercise groups in duration of CIPN, pain intensity scores, or changes in light touch, cold and pain sensations. However, compared to the RecEx group, survivors in the NoEx group had higher vibratory thresholds and worse scores on objective measures of balance. Based on our “real world” findings, clinicians can recommend walking as a therapeutic option, as well as referrals to physical therapy for additional balance and strength training in survivors with CIPN.