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Dopaminergic Control over the Tripartite Synapse
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https://doi.org/10.1016/j.neuron.2020.02.031Abstract
In this issue of Neuron, Corkrum et al. (2020) demonstrate an unexpected role for dopamine D1 receptors on astrocytes located in the nucleus accumbens, a key structure of the brain's reward system. Activation of these receptors mediates dopamine-evoked depression of excitatory synaptic transmission, which contributes to amphetamine's psychomotor effects.
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