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Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus
- Xu, Haiyan;
- Gustafson, Chelsea L;
- Sammons, Patrick J;
- Khan, Sanjoy K;
- Parsley, Nicole C;
- Ramanathan, Chidambaram;
- Lee, Hsiau-Wei;
- Liu, Andrew C;
- Partch, Carrie L
Published Web Location
http://www.ncbi.nlm.nih.gov/pubmed/25961797No data is associated with this publication.
Abstract
The mammalian circadian cycle is determined by sequential activation of clock target-gene expression by CLOCK–BMAL and subsequent repression by CRY. Biochemical and NMR data now show that Cry1 competes with coactivators for binding to the BMAL1 transcriptional-activation domain to regulate circadian cycling.
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