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Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination
- Qiao, Huanyu;
- Prasada Rao, HBD;
- Yang, Ye;
- Fong, Jared H;
- Cloutier, Jeffrey M;
- Deacon, Dekker C;
- Nagel, Kathryn E;
- Swartz, Rebecca K;
- Strong, Edward;
- Holloway, J Kim;
- Cohen, Paula E;
- Schimenti, John;
- Ward, Jeremy;
- Hunter, Neil
Published Web Location
https://doi.org/10.1038/ng.2858Abstract
Neil Hunter and colleagues show that the HEI10 ubiquitin ligase regulates meiotic recombination by limiting the colocalization of RNF212 and MSH4-MSH5 to future crossover sites. At later stages, they find that HEI10 accumulates stably at designated crossover sites and facilitates clearance of RNF212 and MSH4-MSH5 complexes to promote the final steps of meiotic recombination.
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