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Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking
- Mahler, Stephen V;
- Vazey, Elena M;
- Beckley, Jacob T;
- Keistler, Colby R;
- McGlinchey, Ellen M;
- Kaufling, Jennifer;
- Wilson, Steven P;
- Deisseroth, Karl;
- Woodward, John J;
- Aston-Jones, Gary
Published Web Location
https://doi.org/10.1038/nn.3664Abstract
The authors show that rostral ventral pallidum projections to the ventral tegmental area (VTA) are activated during cue-induced reinstatement of cocaine seeking, and DREADD inhibition of these projections blocks this behavior. In contrast, projections from the caudal ventral pallidum are necessary for cocaine-primed, but not cue-induced, reinstatement of cocaine seeking.
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