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Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium
- Meehan, Terrence F;
- Conte, Nathalie;
- West, David B;
- Jacobsen, Julius O;
- Mason, Jeremy;
- Warren, Jonathan;
- Chen, Chao-Kung;
- Tudose, Ilinca;
- Relac, Mike;
- Matthews, Peter;
- Karp, Natasha;
- Santos, Luis;
- Fiegel, Tanja;
- Ring, Natalie;
- Westerberg, Henrik;
- Greenaway, Simon;
- Sneddon, Duncan;
- Morgan, Hugh;
- Codner, Gemma F;
- Stewart, Michelle E;
- Brown, James;
- Horner, Neil;
- Haendel, Melissa;
- Washington, Nicole;
- Mungall, Christopher J;
- Reynolds, Corey L;
- Gallegos, Juan;
- Gailus-Durner, Valerie;
- Sorg, Tania;
- Pavlovic, Guillaume;
- Bower, Lynette R;
- Moore, Mark;
- Morse, Iva;
- Gao, Xiang;
- Tocchini-Valentini, Glauco P;
- Obata, Yuichi;
- Cho, Soo Young;
- Seong, Je Kyung;
- Seavitt, John;
- Beaudet, Arthur L;
- Dickinson, Mary E;
- Herault, Yann;
- Wurst, Wolfgang;
- de Angelis, Martin Hrabe;
- Lloyd, KC Kent;
- Flenniken, Ann M;
- Nutter, Lauryl MJ;
- Newbigging, Susan;
- McKerlie, Colin;
- Justice, Monica J;
- Murray, Stephen A;
- Svenson, Karen L;
- Braun, Robert E;
- White, Jacqueline K;
- Bradley, Allan;
- Flicek, Paul;
- Wells, Sara;
- Skarnes, William C;
- Adams, David J;
- Parkinson, Helen;
- Mallon, Ann-Marie;
- Brown, Steve DM;
- Smedley, Damian
Published Web Location
https://doi.org/10.1038/ng.3901Abstract
Damian Smedley and colleagues report the phenotypic characterization of the first 3,328 genes by the International Mouse Phenotyping Consortium. They develop new mouse models based on genes known to be associated with human mendelian diseases and identify potential disease-associated genes with little or no previous functional annotation.
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