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Mild cognitive impairment as a risk factor for Parkinson's disease dementia
- Hoogland, Jeroen;
- Boel, Judith A;
- Bie, Rob MA;
- Geskus, Ronald B;
- Schmand, Ben A;
- Dalrymple‐Alford, John C;
- Marras, Connie;
- Adler, Charles H;
- Goldman, Jennifer G;
- Tröster, Alexander I;
- Burn, David J;
- Litvan, Irene;
- Geurtsen, Gert J;
- Disease”, on behalf of the MDS Study Group Validation of Mild Cognitive Impairment in Parkinson
Published Web Location
https://doi.org/10.1002/mds.27002Abstract
Background
The International Parkinson and Movement Disorder Society criteria for mild cognitive impairment in PD were recently formulated.Objectives
The aim of this international study was to evaluate the predictive validity of the comprehensive (level II) version of these criteria by assessment of their contribution to the hazard of PD dementia.Methods
Individual patient data were selected from four separate studies on cognition in PD that provided information on demographics, motor examination, depression, neuropsychological examination suitable for application of level II criteria, and longitudinal follow-up for conversion to dementia. Survival analysis evaluated the predictive value of level II criteria for cognitive decline toward dementia as expressed by the relative hazard of dementia.Results
A total of 467 patients were included. The analyses showed a clear contribution of impairment according to level II mild cognitive impairment criteria, age, and severity of PD motor symptoms to the hazard of dementia. There was a trend of increasing hazard of dementia with declining neuropsychological performance.Conclusions
This is the first large international study evaluating the predictive validity of level II mild cognitive impairment criteria for PD. The results showed a clear and unique contribution of classification according to level II criteria to the hazard of PD dementia. This finding supports their predictive validity and shows that they contribute important new information on the hazard of dementia, beyond known demographic and PD-specific factors of influence. © 2017 International Parkinson and Movement Disorder Society.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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