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SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase.

  • Author(s): Verdin, Eric
  • Zhang, Y
  • Bharathi, SS
  • Rardin, MJ
  • Uppala, R
  • Gibson, BW
  • Goetzman, ES
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4374878?pdf=render
No data is associated with this publication.
Abstract

SIRT3 and SIRT5 have been shown to regulate mitochondrial fatty acid oxidation but the molecular mechanisms behind the regulation are lacking. Here, we demonstrate that SIRT3 and SIRT5 both target human very long-chain acyl-CoA dehydrogenase (VLCAD), a key

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