SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase.
- Author(s): Verdin, Eric
- Zhang, Y
- Bharathi, SS
- Rardin, MJ
- Uppala, R
- Gibson, BW
- Goetzman, ES
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC4374878?pdf=render
SIRT3 and SIRT5 have been shown to regulate mitochondrial fatty acid oxidation but the molecular mechanisms behind the regulation are lacking. Here, we demonstrate that SIRT3 and SIRT5 both target human very long-chain acyl-CoA dehydrogenase (VLCAD), a key
Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.