Cooperativity Has Empirical and Ultimate Levels of Explanation.
- Author(s): Ehlert, Frederick J
- et al.
Published Web Locationhttps://doi.org/10.1016/j.tips.2016.06.001
Controversy over the meaning of pharmacological parameters often arises because of a lack of appreciation of different hierarchical levels of analysis. In a recent letter in Trends in Pharmacological Sciences, Zhang and Kavana  concluded that my two-state model for allosterism lacks cooperativity, even though Figures 5 and 6 in my review  illustrate examples of how the two-state model yields specific cooperativity values. Here, I explain how the two-state model (receptor-state analysis) gives rise to the cooperativity parameter (α) of the allosteric ternary complex model (receptor-population analysis).