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Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy
- Hu, Jiong;
- Dziumbla, Sarah;
- Lin, Jihong;
- Bibli, Sofia-Iris;
- Zukunft, Sven;
- de Mos, Julian;
- Awwad, Khader;
- Frömel, Timo;
- Jungmann, Andreas;
- Devraj, Kavi;
- Cheng, Zhixing;
- Wang, Liya;
- Fauser, Sascha;
- Eberhart, Charles G;
- Sodhi, Akrit;
- Hammock, Bruce D;
- Liebner, Stefan;
- Müller, Oliver J;
- Glaubitz, Clemens;
- Hammes, Hans-Peter;
- Popp, Rüdiger;
- Fleming, Ingrid
Published Web Location
https://doi.org/10.1038/nature25013Abstract
A product of the soluble epoxide hydrolase enzyme, 19,20-dihydroxydocosapentaenoic acid (19,20-DHDP), is implicated in the pathogenesis of diabetic retinopathy; levels of 19,20-DHDP increase in the retinas of mice and humans with diabetes, and inhibition of its production can rescue vascular abnormalities in a mouse model of the disease.
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