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Chapter Twelve pH-Free Measurement of Relative Acidities, Including Isotope Effects

Published Web Location

https://doi.org/10.1016/bs.mie.2017.07.012
Abstract

A powerful pH-free multicomponent NMR titration method can measure relative acidities, even of closely related compounds, with excellent accuracy. The history of the method is presented, along with details of its implementation and a comparison with earlier NMR titrations using a pH electrode. Many of its areas of applicability are described, especially equilibrium isotope effects. The advantages of the method, some practical considerations, and potential pitfalls are considered.

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