Evolution and Function of Drososphila melanogaster cis-regulatory Sequences
- Author(s): Hardin, Aaron
- Advisor(s): Eisen, Michael
- et al.
In this work, I describe my doctoral work studying the regulation of transcription with both computational and experimental methods on the natural genetic variation in a population. This works integrates an investigation of the consequences of polymorphisms at three stages of gene regulation in the developing fly embryo: the diversity at cis-regulatory modules, the integration of transcription factor binding into changes in chromatin state and the effects of these inputs on the final phenotype of embryonic gene expression.