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Centrally active modulators of glutamate receptors facilitate the induction of long-term potentiation in vivo.

  • Author(s): Stäubli, U
  • Perez, Y
  • Xu, F B
  • Rogers, G
  • Ingvar, M
  • Stone-Elander, S
  • Lynch, G
  • et al.
Abstract

An experimental drug, 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine, that facilitates glutamatergic transmission in brain after systemic administration was tested for its effects on the induction of long-term potentiation in the hippocampus of rats. Intraperitoneal injections of the drug markedly increased the degree and duration of long-term potentiation; similar results were obtained with an analogue of 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine that was also found to improve retention of memory in a radial maze task and in an odor-matching problem. These results define tools for enhancing long-term potentiation in vivo and confirm an important prediction from the hypothesis that long-term potentiation is a substrate of memory.Images

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