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APJ acts as a dual receptor in cardiac hypertrophy
- Scimia, Maria Cecilia;
- Hurtado, Cecilia;
- Ray, Saugata;
- Metzler, Scott;
- Wei, Ke;
- Wang, Jianming;
- Woods, Chris E;
- Purcell, Nicole H;
- Catalucci, Daniele;
- Akasaka, Takeshi;
- Bueno, Orlando F;
- Vlasuk, George P;
- Kaliman, Perla;
- Bodmer, Rolf;
- Smith, Layton H;
- Ashley, Euan;
- Mercola, Mark;
- Brown, Joan Heller;
- Ruiz-Lozano, Pilar
Published Web Location
https://doi.org/10.1038/nature11263Abstract
APJ is shown to be a bifunctional receptor for both mechanical stretch and the endogenous peptide apelin, a finding that is important for the development of APJ agonists to treat heart failure.
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