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Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer
- Suh, Jae Myoung;
- Jonker, Johan W;
- Ahmadian, Maryam;
- Goetz, Regina;
- Lackey, Denise;
- Osborn, Olivia;
- Huang, Zhifeng;
- Liu, Weilin;
- Yoshihara, Eiji;
- van Dijk, Theo H;
- Havinga, Rick;
- Fan, Weiwei;
- Yin, Yun-Qiang;
- Yu, Ruth T;
- Liddle, Christopher;
- Atkins, Annette R;
- Olefsky, Jerrold M;
- Mohammadi, Moosa;
- Downes, Michael;
- Evans, Ronald M
Published Web Location
https://doi.org/10.1038/nature13540Abstract
Pharmacological fibroblast growth factor 1 (FGF1) normalizes blood glucose in diabetic mice by means of an FGF receptor signalling pathway that is independent of its mitogenic activity.
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