Skip to main content
eScholarship
Open Access Publications from the University of California
Refine Search

UC Berkeley

UC Berkeley Previously Published Works bannerUC Berkeley

Metabolite buffering of labile iron governs ferroptosis

Published Web Location

https://doi.org/10.1016/j.cell.2026.07.037
Abstract

Iron abundance alone does not determine ferroptosis sensitivity. In this issue of Cell, Sharma and colleagues identify polyamines as endogenous metabolic buffers that reduce the chemical accessibility of labile iron, revealing an unexpected function for one of the cell's most abundant metabolite classes while raising new questions about the organization of intracellular iron metabolism.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.


Top