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The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory
Published Web Location
https://doi.org/10.1038/nn.3359Abstract
BAF53b is a neuron-specific component of the nucleosome remodeling complex mSWI/SNF that allows euchromatin formation and provides epigenetic regulation of gene expression. Here, the authors generated BAF53b mutant and rescue mice to show that postnatal nucleosome modeling is crucial to hippocampal synaptic plasticity, neuronal morphology and memory performance.
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