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Open Access Publications from the University of California

Exploring the role of CENP-A Ser18 phosphorylation in CIN and Tumorigenesis.

  • Author(s): Zhang, Weiguo
  • Karpen, Gary H
  • Zhang, Qing
  • et al.

Chromosome instability (CIN) contributes to the development of many cancer. In this paper, we summarize our recent finding that a novel pathway by which FBW7 loss promotes Centromere Protein A (CENP-A) phosphorylation on Serine 18 through Cyclin E1/CDK2, therefore promoting CIN and tumorigenesis. Our finding demonstrates the importance of CENP-A post-translational modification on modulating centromere and mitotic functions in cancer.

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