Lawrence Berkeley National Laboratory
Exploring the role of CENP-A Ser18 phosphorylation in CIN and Tumorigenesis.
- Author(s): Zhang, Weiguo
- Karpen, Gary H
- Zhang, Qing
- et al.
Published Web Locationhttps://doi.org/10.1080/15384101.2017.1387698
Chromosome instability (CIN) contributes to the development of many cancer. In this paper, we summarize our recent finding that a novel pathway by which FBW7 loss promotes Centromere Protein A (CENP-A) phosphorylation on Serine 18 through Cyclin E1/CDK2, therefore promoting CIN and tumorigenesis. Our finding demonstrates the importance of CENP-A post-translational modification on modulating centromere and mitotic functions in cancer.