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LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control
Published Web Location
https://doi.org/10.1038/nn.4069Abstract
The authors show that the neuron-specific LSD1 variant (LSD1n) promotes transcription initiation and elongation in response to neuronal activity. LSD1n is essential for spatial learning and long-term memory formation. LSD1n exhibits novel substrate specificity for histone H4 K20 methylation.
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