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MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells
- Shin, Jeoung-Sook;
- Oh, J;
- Wu, N;
- Baravalle, G;
- Cohn, B;
- Ma, J;
- Lo, B;
- Mellman, I;
- Ishido, S;
- Anderson, M;
- Shin, JS
Published Web Location
http://europepmc.org/articles/PMC3674695?pdf=renderNo data is associated with this publication.
Abstract
Membrane-associated RING-CH1 (MARCH1) is an E3 ubiquitin ligase that mediates ubiquitination of MHCII in dendritic cells (DCs). MARCH1-mediated MHCII ubiquitination in DCs is known to regulate MHCII surface expression, thereby controlling DC-mediated T cel
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