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Open Access Publications from the University of California

MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells

  • Author(s): Shin, Jeoung-Sook
  • Oh, J
  • Wu, N
  • Baravalle, G
  • Cohn, B
  • Ma, J
  • Lo, B
  • Mellman, I
  • Ishido, S
  • Anderson, M
  • Shin, JS
  • et al.

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Membrane-associated RING-CH1 (MARCH1) is an E3 ubiquitin ligase that mediates ubiquitination of MHCII in dendritic cells (DCs). MARCH1-mediated MHCII ubiquitination in DCs is known to regulate MHCII surface expression, thereby controlling DC-mediated T cel

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