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Open Access Publications from the University of California

Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets

  • Author(s): Li, Hao
  • Derisi, Joseph
  • Nelson, CS
  • Fuller, CK
  • Fordyce, PM
  • Greninger, AL
  • DeRisi, JL
  • et al.

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The transcription factor forkhead box P2 (FOXP2) is believed to be important in the evolution of human speech. A mutation in its DNA-binding domain causes severe speech impairment. Humans have acquired two coding changes relative to the conserved mammalian

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