Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets
- Author(s): Li, Hao
- Derisi, Joseph
- Nelson, CS
- Fuller, CK
- Fordyce, PM
- Greninger, AL
- DeRisi, JL
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3695516?pdf=render
The transcription factor forkhead box P2 (FOXP2) is believed to be important in the evolution of human speech. A mutation in its DNA-binding domain causes severe speech impairment. Humans have acquired two coding changes relative to the conserved mammalian
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