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Adjunctive Corticosteroid Therapy in the Treatment of Coccidioidal Meningitis.

  • Author(s): Thompson, George R
  • Blair, Janis E
  • Wang, Sharon
  • Bercovitch, Robert
  • Bolaris, Michael
  • Van Den Akker, Dane
  • Lopez, Rodrigo
  • Heidari, Arash
  • Catanzaro, Antonino
  • Cadena, Jose
  • Chin-Hong, Peter
  • Spellberg, Brad
  • Johnson, Royce
  • et al.
Abstract

Coccidioidal meningitis (CM) has high morbidity, and adjunctive measures to improve outcomes are needed. Using an established multicenter retrospective cohort study of CM (N = 221), we found that patients receiving adjunctive corticosteroids had a significant reduction in secondary cerebrovascular events (P = .0049). Those with CM-associated cerebrovascular events (8%) may benefit from short-term corticosteroids.

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