Skip to main content
eScholarship
Open Access Publications from the University of California
Refine Search

UC Davis

UC Davis Previously Published Works bannerUC Davis

Enantioselective Synthesis of Isotopically Labeled Homocitric Acid Lactone

Published Web Location

https://doi.org/10.1021/ol402802g
Abstract

A concise synthesis of homocitric acid lactone was developed to accommodate systematic placement of carbon isotopes (specifically (13)C) for detailed studies of this cofactor. This new route uses a chiral allylic alcohol, available in multigram quantities from enzymatic resolution, as a starting material, which transposes asymmetry through an Ireland-Claisen rearrangement.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.


Top