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MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies
- Zamvil, Scott;
- Molnarfi, N;
- Schulze-Topphoff, U;
- Weber, MS;
- Patarroyo, JC;
- Prod'homme, T;
- Varrin-Doyer, M;
- Shetty, A;
- Linington, C;
- Slavin, AJ;
- Hidalgo, J
Published Web Location
http://europepmc.org/articles/PMC3865476?pdf=renderNo data is associated with this publication.
Abstract
Whether B cells serve as antigen-presenting cells (APCs) for activation of pathogenic T cells in the multiple sclerosis model experimental autoimmune encephalomyelitis (EAE) is unclear. To evaluate their role as APCs, we engineered mice selectively deficie
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