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A one-pot synthesis of α-l-threofuranosyl nucleoside triphosphates (tNTPs).

  • Author(s): Sau, Sujay P
  • Chaput, John C
  • et al.

Published Web Location

http://www.sciencedirect.com/science/article/pii/S0960894X1630542X
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Abstract

TNA (α-l-threofuranosyl nucleoside) triphosphates of adenosine (tATP), guanosine (tGTP), cytidine (tCTP), and thymidine (tTTP) were synthesized from their corresponding 3'-O-phosphoramidite derivatives using a novel one-pot reaction that is less moisture sensitive than traditional methods. The chemically synthesized tNTPs, despite containing an unnatural 3'-triphosphate moiety, are similar in thermal stability to natural nucleotide triphosphates.

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