Skip to main content
Open Access Publications from the University of California

Diffusion of PLGA Nanoparticle from Alginate Microcapsule to Control Immune Response after Implantation for Type I Diabetes

  • Author(s): Cao, Rui
  • Advisor(s): Lakey, Jonathan RT
  • et al.

Implanted islet microcapsules cause host immune response towards microcapsule.

Certain level of PLGA with anti-inflammatory nanoparticle around microcapsule will

control immune response. Using a mathematical modeling, we investigated the diffusion of

PLGA nanoparticle and the concentration gradient of PLGA nanoparticle around implanted


Assuming a 300um microcapsule with 100 particles/um 3 PLGA, diffusing out of

microcapsule with alginate concentration of 2%, the concentration gradient of PLGA

nanoparticle will largely base diffusion coefficient inside and outside the capsule. Our data

shows the relationship between nanoparticle size and concentration gradient.

Main Content
Current View