Diffusion of PLGA Nanoparticle from Alginate Microcapsule to Control Immune Response after Implantation for Type I Diabetes
- Author(s): Cao, Rui
- Advisor(s): Lakey, Jonathan RT
- et al.
Implanted islet microcapsules cause host immune response towards microcapsule.
Certain level of PLGA with anti-inflammatory nanoparticle around microcapsule will
control immune response. Using a mathematical modeling, we investigated the diffusion of
PLGA nanoparticle and the concentration gradient of PLGA nanoparticle around implanted
Assuming a 300um microcapsule with 100 particles/um 3 PLGA, diffusing out of
microcapsule with alginate concentration of 2%, the concentration gradient of PLGA
nanoparticle will largely base diffusion coefficient inside and outside the capsule. Our data
shows the relationship between nanoparticle size and concentration gradient.