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Human Skeletal Muscle Study Through 2D and 3D Model Design

  • Author(s): Fibben, Kirby Sinclair;
  • Advisor(s): Grosberg, Anna;
  • et al.
Creative Commons 'BY' version 4.0 license
Abstract

Through the creation of a 2D and 3D model of human skeletal muscle, structural and functional data can be collected. The initiation mechanisms of Facioscapulohumeral muscular dystrophy’s (FSHD), a genetic dystrophy that causes increasing muscle degeneration, can be identified through the creation of a reproducible model. Here, we share how the details of various facets and properties of the 2D and 3D design affect a human skeletal muscle in vitro. The specifics of how various extracellular matrix play a role in 2D patterning of skeletal muscle is discussed alongside the intricacies of creating a hydrogel based 3D skeletal muscle bundle. While the models have not yet reached optimal design compared to other techniques, this design is close to reaching a state to produce collectible data.

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